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Canada recommends mixing and matching AstraZeneca, Pfizer and Moderna COVID-19 vaccines.

Canada is changing its guidelines on mixing and matching second doses of COVID-19 vaccines and is now advising Canadians to combine either the AstraZeneca-Oxford, Pfizer-BioNTech or Moderna shots interchangeably in certain situations.

The National Advisory Committee on Immunization (NACI) updated its guidance to provinces and territories Tuesday and recommended that a first shot of the AstraZeneca vaccine can be followed by either Moderna or Pfizer.

For Canadians who have had a first dose of Moderna or Pfizer, NACI recommends they can now take either of the two shots as a second dose — because they both use a similar mRNA technology — if the same first dose is unavailable or unknown.

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